Home > E. Pathology by systems > Respiratory system > Lungs > pulmonary NUT-associated midline carcinoma

pulmonary NUT-associated midline carcinoma

Friday 23 March 2012

pulmonary NUT midline carcinoma

These tumors are diffusely positive for p63 and NUT expression and are partially positive for various cytokeratins.

Reverse transcription polymerase chain reaction analysis and subsequent direct sequencing reveal that the bromodomain-containing protein 4-NUT chimeric gene is present in tumor tissue of both patients, leading to a diagnosis of NMC.

References

- NUT Midline Carcinoma: Report of 2 Cases Suggestive of Pulmonary Origin. Tanaka M, Kato K, Gomi K, Yoshida M, Niwa T, Aida N, Kigasawa H, Ohama Y, Tanaka Y. Am J Surg Pathol. 2012 Mar;36(3):381-8. PMID: 22301500