mixed adenoneuroendocrine carcinoma
Thursday 22 March 2012
Colorectal poorly differentiated neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine carcinomas (MANECs) are well-recognized entities generally known to be associated with biological aggressiveness and poor patient survival.
These neoplasms show a heterogenous spectrum of morphologic and immunohistochemical features; however, only large-cell subtype, significant peritumoral lymphoid reaction, CD117 immunoreactivity, vascular invasion, and MSI/CIMP+ status were significantly correlated with prognosis on univariable analysis.
Furthermore, vascular invasion and CD117 immunoreactivity are independent prognostic markers on multivariable analysis.
Colorectal Poorly Differentiated Neuroendocrine Carcinomas and Mixed Adenoneuroendocrine Carcinomas: Insights Into the Diagnostic Immunophenotype, Assessment of Methylation Profile, and Search for Prognostic Markers. La Rosa S, Marando A, Furlan D, Sahnane N, Capella C. Am J Surg Pathol. 2012 Feb 3. PMID: 22314183