colorectal hypersecretory adenoma
Tuesday 13 March 2012
Secretory adenoma represents a special variant of villous adenoma, usually arising in the rectum.
Patients present with profuse watery diarrhea, severe ﬂuid and electrolyte loss, elevated blood urea nitrogen, reduced serum sodium, and hypokalemia due to hypersecretion of ﬂuid and an electrolyte-rich mucus.
These abnormalities return to normal once the adenoma is excised.
Characteristically, the mucous diarrhea is most severe in the morning after the stool has accumulated during sleeping hours.
The secretion may be mediated by cyclic nucleotides.
Histologically, pale, mucus-ﬁlled cells line the villi of hypersecretory adenomas.
- colorectal adenomas