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colorectal hypersecretory adenoma

Tuesday 13 March 2012

Secretory adenoma represents a special variant of villous adenoma, usually arising in the rectum.

Patients present with profuse watery diarrhea, severe fluid and electrolyte loss, elevated blood urea nitrogen, reduced serum sodium, and hypokalemia due to hypersecretion of fluid and an electrolyte-rich mucus.

These abnormalities return to normal once the adenoma is excised.

Characteristically, the mucous diarrhea is most severe in the morning after the stool has accumulated during sleeping hours.

The secretion may be mediated by cyclic nucleotides.

Histologically, pale, mucus-filled cells line the villi of hypersecretory adenomas.

See also

- colorectal polyps

  • colorectal adenomas