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mammary carcinomas

Wednesday 7 March 2012

breast cancer; mammary carcinomas; breast carcinoma

Breast carcinomas with a worse prognosis than invasive ductal carcinomas include basal-like breast carcinoma , invasive micropapillary carcinoma , metaplastic carcinoma , and Her-2 + / HER2+ carcinomas.

Carcinomas with a better prognosis than invasive ductal carcinoma: secretory carcinoma , medullary carcinoma , tubular carcinoma , colloid carcinoma , and adenoid cystic carcinoma , pictured here.

Unlike the salivary gland, adenoid cystic carcinoma of the breast has a relatively good prognosis.

2012 WHO Classification of Tumors of the Breast

Epithelial tumors

Microinvasive carcinoma

Invasive breast carcinoma

invasive ductal carcinoma

Invasive carcinoma of no special type (NST)

Pleomorphic carcinoma
Carcinoma with osteoclast like stromal giant cells
Carcinoma with choriocarcinomatous features
Carcinoma with melanotic features

Invasive lobular carcinoma

Classic lobular carcinoma
Solid lobular carcinoma
Alveolar lobular carcinoma
Pleomorphic lobular carcinoma
Tubulolobular carcinoma
Mixed lobular carcinoma

Tubular carcinoma
Cribiform carcinoma
Mucinous carcinoma
Carcinoma with medullary features

Medullary carcinoma
Atypical medullary carcinoma
Invasive carcinoma NST with medullary features

Carcinoma with apocrine differentiation
Carcinoma with signet ring differentiation
Invasive micropapillary carcinoma
Metaplastic carcinoma of no special type

Low-grade adenosquamous carcinoma
Fibromatosis like metaplastic carcinoma
Squamous cells carcinoma
Spindle cell carcinoma
Metaplastic carcinoma with mesenchymal differentiation
- Chondroid differentiation
- Osseous differentiation

Other types of mesenchymal differentiation
Mixed metaplastic carcinoma
Myoepithelial carcinoma

Rare types

Carcinoma with neuroendocrine features
- Neuroendocrine tumor, well differentiated
- Neuroendocrine carcinoma, poorly differentiated (small cell carcinoma)
- Carcinoma with neuroendocrine differentiation

Secretory carcinoma
Invasive papillary carcinoma
Acinic cell carcinoma
Mucoepidermoid carcinoma
Polymorphous carcinoma
Oncocytic carcinoma
Lipid rich carcinoma
Glycogen rich clear cell carcinoma
Sebaceous carcinoma
Salivary gland / skin adnexal type tumors
- Cylindroma
- Clear cell hidradenoma

Types - OMS 2003

http://www.pathologyoutlines.com/topic/breastmalignantwhoclassification.html

mammary invasive ductal carcinoma
mammary invasive lobular carcinoma
mammary invasive tubular carcinoma
mammary invasive cribriform carcinoma
mammary medullary carcinoma
mammary mucinous carcinoma
mammary neuroendocrine carcinoma
mammary invasive papillary carcinoma
mammary invasive micropapillary carcinoma
mammary apocrine carcinoma
mammary metaplastic carcinomas
mammary lipid-rich carcinoma
mammary secretory carcinoma
mammary oncocytic carcinoma
mammary adenoid cystic carcinoma
mammary acinic cell carcinoma
mammary glycogen-rich clear cell carcinoma
mammary sebaceous carcinoma
mammary inflammatory
mammary lobular neoplasia
mammary intraductal proliferative lesions
mammary microinvasive carcinoma
mammary intraductal papillary tumors

Types according to tumoral invasion

mammary invasive carcinomas
mammary non-invasive carcinomas

Digital cases

JRC:5418 : Breast lobular carcinoma in situ.
JRC:5436 : Mammary invasive lobular carcinoma.
JRC:4946 : Invasive ductal carcinoma of the breast.
JRC:4055 : Mammary papillary carcinoma.
JRC:4061 : Mammary papillary carcinoma.
JRC:4938 : Apocrine carcinoma of the breast.
JRC:5032 : Medullary carcinoma of the breast.
JRC:5139 : Undifferentiated carcinoma of the breast.

Differential diagnosis

mammary benign proliferative lesions (mammary benign epithelial proliferations )

Immunochemistry

	Luminal A	Luminal B	HER2-E	Basal-like
ER	+	+	-	-
PR	+	+	-	-
HER2	-	+	+	-

Breast cancer risk

Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (23535729)

Links

http://www.breastpathology.info/Common%20cancers.html

Breast carcinoma pathology

See also

mammary tumors
breast cancer

References

Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K, Hall P, Gonzalez-Neira A et al. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2. doi : 10.1038/ng.2563 PMID: 23535729

Special types of invasive breast cancer, with clinical implications. Page DL. Am J Surg Pathol. 2003 Jun;27(6):832-5. PMID: 12766589