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composite adrenal medullary tumor

Friday 2 March 2012

composite adrenal medullary neoplasms; Composite adrenal pheochromocytoma; composite adrenal medullary tumors

Definition: Composite adrenal medullary tumors is a rare adrenal tumor composed of ordinary pheochromocytoma and other components, most frequently neuroblastic elements.

Little is known about its biologic potential, therefore creating a clinical dilemma on diagnosis.

Composite pheochromocytoma may be regarded as a histologic variant of classic pheochromocytoma.

Composite adrenal medullary neoplasms are rare entities that are composed in part of a pheochromocytoma, one of the three patterns of the neuroblastic tumors or a peripheral nerve sheath neoplasm.

Most of these tumors have been reported in adults, but have been infre-quently observed in children.

See also

- composite pheochromocytoma-ganglioneuroma tumor

References

- Composite pheochromocytoma: a clinicopathologic and molecular comparison with ordinary pheochromocytoma and neuroblastoma. Comstock JM, Willmore-Payne C, Holden JA, Coffin CM. Am J Clin Pathol. 2009 Jul;132(1):69-73. PMID: 19864235

- Miyauchi J, Kiyotani C, Shioda Y, Kumagai M, Honna T, Matsuoka K, Masaki H, Aiba M, Hata J, Tsunematsu Y. Unusual chromaffin cell differentiation of a neuroblastoma after chemotherapy and radiotherapy: report of an autopsy case with immunohistochemical evaluations. Am J Surg Pathol. 2004 Apr;28(4):548-53. PMID: 15087676

- Aiba M, Hirayama A, Ito Y, et al. A compound adrenal medullary tumor (pheochromocytoma and ganglioneuroma) and a cortical adenoma in the ipsilateral adrenal gland: a case report with enzyme histochemical and immunohistochemical studies. Am J Surg Pathol. 1988;12:559-566.

- Balazs M. Mixed pheochromocytoma and ganglioneuroma of the adrenal medulla: a case report with electron microscopic examination. Hum Pathol. 1988;19:1352-1355.

- Brady S, Lechan RM, Schwaitzberg SD, et al. Composite pheochromocytoma/ganglioneuroma of the adrenal gland associated with multiple endocrine neoplasia 2A: case report with immunohistochemical analysis. Am J Surg Pathol. 1997;21:102-108.

- Kragel PJ, Johnston CA. Pheochromocytoma-ganglioneuroma of the adrenal. Arch Pathol Lab Med. 1985;109:470-472.