gastric pit dysplasia

Despite wide acceptance of the chronic gastritis-intestinal metaplasia-dysplasia-carcinoma sequence, especially for intestinal-type gastric adenocarcinoma, the precise nature of the subtle precursor lesions of gastric cancer remains to be delineated.

For example, pit dysplasia with surface foveolar maturation is not well defined, nor is its prevalence and biological characteristics well characterized.

Gastric pit dysplasia is an important candidate precursor of gastric adenocarcinoma and may represent another morphologic step in the pathogenesis of gastric adenocarcinoma, especially of intestinal type.

References

 Gastric pit dysplasia in adjacent gastric mucosa in 414 gastric cancers: prevalence and characteristics. Shin N, Jo HJ, Kim WK, Park WY, Lee JH, Shin DH, Choi KU, Kim JY, Lee CH, Sol MY, Jeon TY, Kim DW, Huh GY, Kim GH, Lauwers GY, Park do Y. Am J Surg Pathol. 2011 Jul;35(7):1021-9. PMID: 21677540