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Mycobacterium abscessus granulomatous prostatitis

Wednesday 22 February 2012

Infectious granulomatous prostatitis is uncommon, and most cases of granulomatous prostatitis are classified as nonspecific granulomatous prostatitis.

From 2007 to 2009, 5 patients experienced poor wound healing after radical prostatectomy for prostate cancer at a specialist cancer center.

Mycobacterium abscessus was cultured from the debridement specimens, and acid-fast-positive bacilli were identified histologically within the prostates.

The characteristic morphologic feature of MAGP was suppurative necrotizing granulomatous inflammation extensively (10% to 80% of the gland; mean, 39%) involving the prostate.

The centers of MAGP were large areas of neutrophilic abscess and necrotic debris, which were surrounded by histiocytes, lymphocytes, plasma cells, scattered multinucleated giant cells, and eosinophils.

In the adjacent areas, there was a lobular extension of mixed inflammatory infiltrates into dilated and ruptured ducts.

It is critical for pathologists to recognize MAGP and to distinguish it from the more common nonspecific granulomatous prostatitis and other granulomatous lesions within the prostate.

References

- Mycobacterium abscessus Granulomatous Prostatitis. Chuang AY, Tsou MH, Chang SJ, Yang LY, Shih CC, Tsai MP, Chen YL, Liu TM, Liao CH, Hsueh PR. Am J Surg Pathol. 2012 Mar;36(3):418-22. PMID: #22261705#