Friday 21 November 2003
The zebrafish has become a widely used model organism because of its fecundity, its morphological and physiological similarity to mammals, the existence of many genomic tools and the ease with which large, phenotype-based screens can be performed.
Because of these attributes, the zebrafish might also provide opportunities to accelerate the process of drug discovery. By combining the scale and throughput of in vitro screens with the physiological complexity of animal studies, the zebrafish promises to contribute to several aspects of the drug development process, including target identification, disease modelling, lead discovery and toxicology.
early zebrafish development
The emerging use of zebrafish to model metabolic disease. Seth A, Stemple DL, Barroso I. Dis Model Mech. 2013 Sep-Oct;6(5):1080-8. doi:10.1242/dmm.01134. PMID: #24046387# [Free]
Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model. Martin CS, Moriyama A, Zon LI. Genome Med. 2011 Dec 29;3(1):83. PMID: #22206610#
Lieschke GJ, Currie PD. Animal models of human disease: zebrafish swim into view. Nat Rev Genet. 2007 May;8(5):353-67. PMID: #17440532#
Amsterdam A, Hopkins N. Mutagenesis strategies in zebrafish for identifying genes involved in development and disease. Trends Genet. 2006 Sep;22(9):473-8. PMID: #16844256#
Langenau DM, Zon LI. The zebrafish: a new model of T-cell and thymic development. Nat Rev Immunol. 2005 Apr;5(4):307-17. PMID: #15803150#
Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005 Jan;4(1):35-44. PMID: #15688071#
Bassett DI, Currie PD. The zebrafish as a model for muscular dystrophy and congenital myopathy. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R265-70. PMID: #14504264#
Sehnert AJ, Stainier DY. A window to the heart: can zebrafish mutants help us understand heart disease in humans? Trends Genet. 2002 Oct;18(10):491-4. PMID: #12350332#
Mellgren EM, Johnson SL. The evolution of morphological complexity in zebrafish stripes. Trends Genet. 2002 Mar;18(3):128-34. PMID: #11858836#
Dodd A, Curtis PM, Williams LC, Love DR. Zebrafish: bridging the gap between development and disease. Hum Mol Genet. 2000 Oct;9(16):2443-9. PMID: #11005800#
Blader P, Strahle U. Zebrafish developmental genetics and central nervous system development. Hum Mol Genet. 2000 Apr 12;9(6):945-51. PMID: #10767318#
Ingham PW. Zebrafish genetics and its implications for understanding vertebrate development. Hum Mol Genet. 1997;6(10):1755-60. PMID: #9300668#