Home > E. Pathology by systems > Reproductive system > Male genital system > Prostate > small cell neuroendocrine PIN
small cell neuroendocrine PIN
Thursday 16 February 2012
Small cell neuroendocrine variant.
Extremely rare examples with small cell neuroendocrine cells exist. Small neoplastic cells, with rosette-like formations, are observed in the centre of glands, which display peripheral, glandular-type PIN cells.
In one case there was admixed, invasive mixed small celladenocarcinoma.
The small neoplastic cells are chromogranin and synaptophysin-positive, and harbour densecore, membrane-bound, neurosecretory granules at the ultrastructural level.
