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small cell neuroendocrine PIN

Thursday 16 February 2012

Small cell neuroendocrine variant.

Extremely rare examples with small cell neuroendocrine cells exist. Small neoplastic cells, with rosette-like formations, are observed in the centre of glands, which display peripheral, glandular-type PIN cells.

In one case there was admixed, invasive mixed small celladenocarcinoma.

The small neoplastic cells are chromogranin and synaptophysin-positive, and harbour densecore, membrane-bound, neurosecretory granules at the ultrastructural level.