- Human pathology

Home > F. Pathology by regions > Abdomen > Peritoneal cavity > gliomatosis peritonei and endometriosis

gliomatosis peritonei and endometriosis

Monday 13 February 2012

Gliomatosis peritonei (GP) describes the implantation of mature neuroglial tissue in the peritoneum and is usually associated with mature ovarian teratoma but is also found in cases of immature teratoma.


- recurrent mature ovarian teratoma
- gliomatosis peritonei (GP)
- endometriosis (with malignant transformation) (21293285)
- carcinoid tumor (21293285)
- primary endometrial adenocarcinoma (21293285)

Metaplasia of the totipotential subcoelomic or submesothelial stem cells is a recognized pathway for the development of endometriosis.

Evidence from molecular genetic studies suggests that a similar process of stem cell differentiation may explain at least some cases of gliomatosis peritonei.

The coexistence (and colocalization) of endometriosis, gliomatosis peritonei, and carcinoid tumor in a rare case raises the possibility that peritoneal stem cells may occasionally show an even wider spectrum of aberrant differentiation. (21293285)


- Relationship between endometriosis, endometrioid adenocarcinoma, gliomatosis peritonei, and carcinoid tumor in a patient with recurrent ovarian teratoma. Alexander M, Cope N, Renninson J, Hong A, Simpson RH, Hirschowitz L. Int J Gynecol Pathol. 2011 Mar;30(2):151-7. PMID: 21293285

- Gliomatosis peritonei: a report of two cases and review of the literature. Müller AM, Söndgen D, Strunz R, Müller KM. Eur J Obstet Gynecol Reprod Biol. 2002 Jan 10;100(2):213-22. PMID: 11750968

- Immature ovarian teratoma with mature peritoneal metastatic deposits showing glial, epithelial, and endometrioid differentiation: a case report and review of the literature. Calder CJ, Light AM, Rollason TP. Int J Gynecol Pathol. 1994 Jul;13(3):279-82. PMID: 7928061

- Gliomatosis peritonei with endometriosis externa. Dworák O, Knöpfle G, Varchmin-Schultheiss K, Meyer G. Gynecol Oncol. 1988 Feb;29(2):263-6. PMID: 3338678

- Nodular and tumorlike gliomatosis peritonei with endometriosis caused by a mature ovarian teratoma. Bässler R, Theele C, Labach H. Pathol Res Pract. 1982 Dec;175(4):392-403. PMID: 7167411