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peripancreatic paraganglioma

Monday 30 January 2012

Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of the autonomic nervous system. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking one of the more common primary pancreatic lesions.

Synopsis

- diffuse epigastric and abdominal pain
- incidental mass
- predominantly located in the body of the pancreas
- size from 5.5 to 17.0 cm (mean, 10.0 cm)
- 56% of cystic change

Immunohistochemistry

- chief cells (synaptophysin positive and chromogranin A positive)
- sustentacular cells (S-100 protein positive).

References

- Peripancreatic paraganglioma: a potential diagnostic challenge in cytopathology and surgical pathology. Singhi AD, Hruban RH, Fabre M, Imura J, Schulick R, Wolfgang C, Ali SZ. Am J Surg Pathol. 2011 Oct;35(10):1498-504. PMID: 21921779