Monday 30 January 2012
Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of the autonomic nervous system. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking one of the more common primary pancreatic lesions.
diffuse epigastric and abdominal pain
predominantly located in the body of the pancreas
size from 5.5 to 17.0 cm (mean, 10.0 cm)
56% of cystic change
chief cells (synaptophysin positive and chromogranin A positive)
sustentacular cells (S-100 protein positive).
Peripancreatic paraganglioma: a potential diagnostic challenge in cytopathology and surgical pathology. Singhi AD, Hruban RH, Fabre M, Imura J, Schulick R, Wolfgang C, Ali SZ. Am J Surg Pathol. 2011 Oct;35(10):1498-504. PMID: 21921779