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liposarcoma in uterine lipoleiomyoma

Wednesday 4 January 2012

Primary sarcomas of the uterus are uncommon, leiomyosarcoma being the most frequent. Most uterine sarcomas arise de novo, with malignant transformation of a benign mesenchymal tumor being a very rare event, and is reported only in leiomyomata.

Primary liposarcomas of the uterus are extremely rare and are most likely to arise from malignant transformation of a lipoleiomyoma.

These tumors should be added to the differential diagnosis of benign lipomatous tumors, myxoid mesenchymal tumors, and malignant mixed Müllerian tumors (if pleomorphic) of the uterus.

References

- Liposarcoma arising in uterine lipoleiomyoma: a report of 3 cases and review of the literature. McDonald AG, Dal Cin P, Ganguly A, Campbell S, Imai Y, Rosenberg AE, Oliva E. Am J Surg Pathol. 2011 Feb;35(2):221-7. PMID: 21263242