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spitzoid melanoma

Wednesday 4 January 2012

Spitz nevi and Spitzoid melanomas show overlapping histopathologic features, often making the diagnosis challenging.

- The p16 protein functions as a tumor suppressor and loss of its expression may be seen in some melanomas.

- Some authors found no significant difference in p16 staining in Spitz nevi and Spitzoid melanomas. They conclude that p16 does not appear to be a useful immunohistochemical marker in distinguishing between Spitz nevi and Spitzoid melanomas. (23005921)


The efficacy of 9p21/Cep9 as a diagnostic FISH assay in melanoma has been validated. 9p21 may be particularly helpful in lesions with spitzoid morphology. (21989344)


- Enhanced detection of spitzoid melanomas using fluorescence in situ hybridization with 9p21 as an adjunctive probe. Gammon B, Beilfuss B, Guitart J, Gerami P. Am J Surg Pathol. 2012 Jan;36(1):81-8. PMID: 21989344