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miR-221

Wednesday 4 January 2012

MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors.

A study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition.

Pathology

- Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors.

References

- MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer. Shah MY, Calin GA. Genome Med. 2011 Aug 31;3(8):56. PMID: #21888691# (free)