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GATA6

Friday 30 December 2011

Pathology

- GATA6 haploinsufficiency causes pancreatic agenesis in humans.

- GATA6 is a marker for poor prognosis in ocarian carcinoma

  • GATA6 was expressed in both high-grade serous carcinoma as well as non-serous tumors.
  • High grade serous carcinoma showed a higher percentage of GATA6 positive staining.
  • Positive staining of GATA6 showed worse overall survival (OS) in all ovarian cancers or serous and non-serous carcinoma individually.
  • GATA6 was revealed as an independent risk factor for prognosis by multivariate Cox analysis.
  • doi : 10.1016/j.humpath.2019.01.001

See also

- GATAs
- pancreatic agenesis

References

- GATA6 haploinsufficiency causes pancreatic agenesis in humans. Allen HL, Flanagan SE, Shaw-Smith C, De Franco E, Akerman I, Caswell R; the International Pancreatic Agenesis Consortium, Ferrer J, Hattersley AT, Ellard S. Nat Genet. 2011 Dec 11;44(1):20-22. PMID: 22158542