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caseating granuloma

Wednesday 14 December 2011

caseating granulomatous inflammation;

Definition: granulomatous inflammation with caseous necrosis

Etiology

- mycobacterial infections

- fungal species

- cutaneous leishmaniasis

- cesarean scar caseating granuloma
- systemic sarcoidosis with caseating granuloma

Few infectious agents have been associated with caseating granulomatous inflammation.

The vast majority of infectious granulomatous adenitis with caseous necrosis is seen with localised or disseminated mycobacterial infections, both tuberculous and non-tuberculous.

Many other fungal species such as dimorphic fungi, Cryptococcus neoformans and Candida sp. can cause granulomas in various organs, including for some the lymph nodes.

However, except for Histoplasma capsulatum, they do not usually present with caseating granulomas.

Many non-infectious diseases are also associated with the presence of non caseating granulomas.

Localization

- caseating granulomatous inflammation