Thursday 8 December 2011
Circulating cell-free DNA (cfDNA) has become a promising biomarker in prenatal diagnosis.
However, despite extensive studies in different body fluids, cfDNA predictive value is uncertain owing to the confounding factors that can affect its levels, such as gestational age, maternal weight, smoking status, and medications.
circulating free DNA
Cell-free DNA fragmentation patterns in amniotic fluid identify genetic abnormalities and changes due to storage. Peter I, Tighiouart H, Lapaire O, Johnson KL, Bianchi DW, Terrin N. Diagn Mol Pathol. 2008 Sep;17(3):185-90. PMID: 18382362