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8p21 rearrangement

Thursday 8 December 2011

Tumors

- colorectal cancer

  • The short arm of chromosome 8 is often lost in colorectal cancer and has been associated with the advanced stages.
  • A common region of deletion has been identified in 8p21.

References

- High-resolution genotyping of chromosome 8 in colon adenocarcinomas reveals recurrent break point but no gene mutation in the 8p21 region. Mourra N, Zeitoun G, Portier G, Blanche H, Tubacher E, Gressin L, Flejou JF, Tiret E, Thomas G, Olschwang S. Diagn Mol Pathol. 2008 Jun;17(2):90-3. PMID: #18382363#