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HPV-associated cervical squamous cell carcinoma

Wednesday 7 December 2011

- The presence of methylation of the p16INK4A gene and human papillomavirus in high-grade cervical squamous intraepithelial lesions. (20186007)

  • Methylation is a chemical modification in which a methyl group (CH3) is added to the cytosine in the promoter region of the gene.
  • Methylation involves a very frequent epigenetic event that is found in many human cancers.
    - The presence of methylation of the p16 gene constituted an occurrence that was early but independent of the presence of HPV DNA. (20186007)

References

- The presence of methylation of the p16INK4A gene and human papillomavirus in high-grade cervical squamous intraepithelial lesions. Furtado YL, Almeida G, Lattario F, Silva KS, Maldonado P, Silveira FA, do Val IC, Fonseca R, Carvalho Mda G. Diagn Mol Pathol. 2010 Mar;19(1):15-9. PMID: 20186007