JAK2-negative myeloproliferative disease
Monday 28 November 2011
Mutations in the thrombopoietin receptor gene (myeloproliferative leukemia, MPL) have been reported in patients with JAK2 V617F-negative chronic myeloproliferative disorders (MPDs).
MPL mutation screening should be performed before JAK2 exons 12 to 14 testing in JAK2 V617F-negative patients with suspected MPDs. (#21326037#)
MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative disorders. Ma W, Zhang X, Wang X, Zhang Z, Yeh CH, Uyeji J, Albitar M. Diagn Mol Pathol. 2011 Mar;20(1):34-9. PMID: #21326037#