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JAK2-negative myeloproliferative disease

Monday 28 November 2011

Mutations in the thrombopoietin receptor gene (myeloproliferative leukemia, MPL) have been reported in patients with JAK2 V617F-negative chronic myeloproliferative disorders (MPDs).

MPL mutation screening should be performed before JAK2 exons 12 to 14 testing in JAK2 V617F-negative patients with suspected MPDs. (21326037)

References

- MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative disorders. Ma W, Zhang X, Wang X, Zhang Z, Yeh CH, Uyeji J, Albitar M. Diagn Mol Pathol. 2011 Mar;20(1):34-9. PMID: 21326037