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non-small cell lung cancer

Thursday 17 November 2011

NSCLC

Types

- EGFR mutation-associated NSCLC (23355336)

Evolution

- lymph node micrometastasis

  • Lymph node metastasis is a major prognostic factor in resected non-small cell lung cancer (NSCLC).
  • However, 30-40 % rate of recurrence after performing complete resection in node-negative patients suggests that their nodal staging is suboptimal.
  • The detection of lymph node micrometastasis by FHIT and CDKN2A mRNA deletion RT-PCR will be helpful to predict the recurrence and prognosis of patients with completely resected stage I-IIB NSCLC. (23355336)

References

- Molecular diagnosis and prognostic significance of lymph node micrometastasis in patients with histologically node-negative non-small cell lung cancer. Dai CH, Li J, Yu LC, Li XQ, Shi SB, Wu JR. Tumour Biol. 2013 Apr;34(2):1245-53. doi : 10.1007/s13277-013-0667-5 PMID: 23355336

- Non-small-cell lung cancer. Goldstraw P, Ball D, Jett JR, Le Chevalier T, Lim E, Nicholson AG, Shepherd FA. Lancet. 2011 Nov 12;378(9804):1727-40. PMID: 21565398

- Molecular pathology of non-small-cell lung cancer. Breuer RH, Postmus PE, Smit EF. Respiration. 2005 May-Jun;72(3):313-30. Review. PMID: 15942304 [Free]