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peritoneum well-differentiated papillary mesothelioma

Tuesday 8 November 2011

Definition: Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial tumor that occurs in the peritoneum of women over a wide age range. Although considered a tumor of uncertain malignant potential, information about its biological behavior is still limited.

Recognition of the histologic features of WDPM and proper clinical correlation allow for the correct diagnosis of this entity. If necessary, immunohistochemical studies such as calretinin and keratin 5/6 facilitate the recognition of the mesothelial nature of this neoplasm.

Follow-up of patients with this diagnosis is warranted on the basis of possible recurrences or misdiagnosis of an undersampled malignant mesothelioma.

Molecular pathology

- somatic mutation of E2F1 in a critical DNA binding residue in well-differentiated papillary mesothelioma of the peritoneum. (21955916)

See also

- E2Fs

References

- First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum. Yu W, Chan-On W, Teo M, Ong CK, Cutcutache I, Allen GE, Wong B, Myint SS, Lim KH, Voorhoeve PM, Rozen S, Soo KC, Tan P, Teh BT. Genome Biol. 2011 Sep 28;12(9):R96. PMID: 21955916

- Well-Differentiated Papillary Mesothelioma of the Female Peritoneum: A Clinicopathologic Study of 26 Cases. Malpica A, Sant’ambrogio S, Deavers MT, Silva EG. Am J Surg Pathol. 2011 Oct 20. PMID: 22024662