Home > D. Systemic pathology > Vascular anomalies > microscopic polyarteritis

microscopic polyarteritis

Tuesday 18 November 2003

Digital slides

- UI:575 : Microscopic polyarteritis : Kidney - Microscopic polyangiitis, vasculitis, fibrinoid necrosis, necrotizing glomerulonephritis, crescents

Definition: Microscopic polyangiitis is a pauci-immune, necrotizing, small-vessel vasculitis without evidence of granulomatous inflammation involving small-sized muscular arteries.

Synopsis

- perinuclear pattern with anti-neutrophil cytoplasmic antibody (p-ANCA +) (pANCA-associated microscopic polyangiitis)
- disseminated intravascular coagulation (DIC)with marked systemic bleeding (14518675)

- massive myocardial necrosis

- pulmonary lesions

- peripheral neuropathy
- crescentic glomerulonephritis
- glomerulonephritis associated with small vessel vasculitis
- limited cutaneous systemic sclerosis

Associations

- cryptogenic fibrosing alveolitis
- late emergence of generalised Wegener’s granulomatosis

References

- Jennette JC, Thomas DB, Falk RJ. Microscopic polyangiitis (microscopic polyarteritis). Semin Diagn Pathol. 2001 Feb;18(1):3-13. PMID: 11296991