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nested variant of urothelial carcinoma

Monday 12 September 2011

Large nested pattern of urothelial carcinoma is distinguished from an inverted growth pattern of non-invasive urothelial carcinoma and from von Brunn nests by either MP invasion, irregularly infiltrating nests, or a stromal reaction.

Despite the bland cytologic features of these neoplasms, they have well-documented metastatic potential.

Images

- https://commons.wikimedia.org/wiki/File:Nested_variant_of_urothelial_carcinoma_-_intermed_mag.jpg
- https://commons.wikimedia.org/wiki/File:Nested_variant_of_urothelial_carcinoma_-_high_mag.jpg
- https://commons.wikimedia.org/wiki/File:Nested_variant_of_urothelial_carcinoma_-_very_high_mag.jpg

Differential diagnosis

- von brunn nests
- inverted growth pattern of noninvasive papillary urothelial carcinoma (21836490)

References

- Large nested variant of urothelial carcinoma: 23 cases mimicking von brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. Cox R, Epstein JI. Am J Surg Pathol. 2011 Sep;35(9):1337-42. PMID: 21836490