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colonic Burkitt lymphoma

Monday 11 July 2011

Digital slides

- UI:1193 : colonic Burkitt lymphoma

Immunophenotype

SIg, CD20, CD10 and BCL6 expression. Nearly 100% of cells are Ki-67+.

Pathogenesis

Genetic abnormalities: t(8:14) with translocation of the MYC gene. EBV infection is frequent in endemic Burkitt lymphoma and less common in sporadic cases.

Sporadic Burkitt lymphoma is seen in children and young adults , usually in extranodal sites. Endemic Burkitt lymphoma (Africa) characteristically presents in the jaw. The tumor also arises in immunodeficient patients, primarily in AIDS.

See also

- Burkitt lymphoma

References

- WHO Classification of Tumors: Tumors of the Hematopoietic and Lymphoid Tissues. Jaffe, Harris, Stein & Vardiman, IARCPress, Lyon, 2001.