Home > F. Pathology by regions > Abdomen > abdominal inflammatory myofibroblastic tumor

abdominal inflammatory myofibroblastic tumor

Tuesday 21 June 2011

Inflammatory myofibroblastic tumor (IMT) occurring in abdominal location is a rare condition in children.

Inflammatory myofibroblastic tumor (IMT) is a proliferative lesion composed of spindle cells accompanied by inflammatory infiltrate.

Synopsis

- infiltrative growth pattern
- variable admixture of spindle (myofibroblastic and fibroblastic) cells and
predominantly mononuclear inflammatory cells
- possible compact fascicular spindle cell proliferation with collagenized matrix and a distinct focal or sparse inflammatory infiltrate resembling a fibromatosis-like proliferation
- possible spindle cells to plump cells in an edematous myxoid background with scattered lymphocytes, plasma cells, eosinophils and small blood vessels, resembling a granulation tissue.
- possible foci of necrosis
- rare atypical tumor cells
- low mitotic index ( < 1/10 HPF-high power fields)
- no ganglion-like cells, Reed-Sternberg-like cells or calcification/ossification foci

Immunochemistry

- ALK+
- Strong diffuse vimentin and focal to diffuse smooth muscle actin was observed in the cytoplasm of spindle cells
- focal desmin+

Localization

- gastric
- hepatic
- colonic
- splenic adrenal
- pancreatic