abdominal inflammatory myofibroblastic tumor
Tuesday 21 June 2011
Inflammatory myofibroblastic tumor (IMT) occurring in abdominal location is a rare condition in children.
infiltrative growth pattern
variable admixture of spindle (myofibroblastic and fibroblastic) cells and
predominantly mononuclear inflammatory cells
possible compact fascicular spindle cell proliferation with collagenized matrix and a distinct focal or sparse inflammatory infiltrate resembling a fibromatosis-like proliferation
possible spindle cells to plump cells in an edematous myxoid background with scattered lymphocytes, plasma cells, eosinophils and small blood vessels, resembling a granulation tissue.
possible foci of necrosis
rare atypical tumor cells
low mitotic index ( < 1/10 HPF-high power fields)
no ganglion-like cells, Reed-Sternberg-like cells or calcification/ossification foci
Strong diffuse vimentin and focal to diffuse smooth muscle actin was observed in the cytoplasm of spindle cells