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PRDMs

Thursday 16 June 2011

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PRDM1 PRDM2 PRDM3 PRDM4 PRDM5 PRDM6 PRDM7 PRDM8 PRDM9 PRDM10
PRDM11 PRDM12 PRDM13 PRDM14 PRDM15 PRDM16

Pathology

- PRDM1

  • Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin’s lymphoma. (21785431)

- PRDM9

  • Rare allelic forms of PRDM9 associated with childhood leukemogenesis. (23222848)

- PRDM16

  • PRDM16 is encoding a zinc finger protein with a PR domain that is highly homologous to the MDS1 (MIM.600049)/EVI1 (MIM.165215) genes.
  • PRDM16 variant in predisposition to migraine (GWAS) (21666692)
  • PRDM16 is located near the breakpoint at 1p36.3.
  • The 3q21-q26 syndrome represents a recurrent translocation, inversion, or insertion between the regions 3q21 and 3q26 and is associated with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
  • The disorder is frequently characterized by trilineage dysplasia, in particular dysmegakaryocytopoiesis, and poor prognosis.
  • A similar type of MDS/AML has been reported with the recurrent t(1;3)(p36;q21) translocation.
  • Near the breakpoint at 1p36.3, the gene PRDM16 has been identified, encoding a zinc finger protein with a PR domain that is highly homologous to the MDS1 (MIM.600049)/EVI1 (MIM.165215) genes.

See also

- PRDMs

References

- Best T, Li D, Skol AD, et al. Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin’s lymphoma. Nat Med. 2011. 17;8:941-3. PMID: 21785431

- Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Chasman DI, Schürks M, Anttila V, de Vries B, Schminke U, Launer LJ, Terwindt GM, van den Maagdenberg AM, Fendrich K, Völzke H, Ernst F, Griffiths LR, Buring JE, Kallela M, Freilinger T, Kubisch C, Ridker PM, Palotie A, Ferrari MD, Hoffmann W, Zee RY, Kurth T. Nat Genet. 2011 Jun 12. PMID: 21666692