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eosinophilic pulmonary syndrome

Wednesday 8 June 2011

Definition: The eosinophilic pulmonary syndrome is a clinically and pathologically distinct entity from the classic eosinophilic pneumonias such as Löeffler syndrome, acute eosinophilic pneumonia, bronchopulmonary aspergillosis and hypereosinophilic syndrome.

The latter entities are characterized by filling of the alveolar spaces by eosinophils, whereas eosinophilic pulmonary syndrome following allogeneic hematopoietic stem cell transplantation (HSCT) involves the small airways.

A similar phenomenon, described in lung transplant recipients, is associated with an unfavorable prognosis, and it has been proposed that peripheral eosinophilia can be a sign of lung allograft rejection.

See also

- eosinophilic pneumonia