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post-transplantation EBV-associated extranodal marginal zone lymphoma of MALT

Wednesday 11 May 2011

The 2008 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues defines monomorphic posttransplant lymphoproliferative disorders (M-PTLDs) as lymphoid or plasmacytic proliferations that fulfill the criteria for one of the B-cell or T/NK-cell neoplasms recognized in immunocompetent patients. However, indolent B-cell lymphomas, such as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), are specifically excluded from this category.

The uniform EBV positivity and response to immune reconstitution in some cases suggest that EBV-positive MALT lymphomas arising in the posttransplant setting should be included among PTLDs.

References

- EBV-Positive Extranodal Marginal Zone Lymphoma of Mucosa-associated Lymphoid Tissue in the Posttransplant Setting: A Distinct Type of Posttransplant Lymphoproliferative Disorder? Gibson SE, Swerdlow SH, Craig FE, Surti U, Cook JR, Nalesnik MA, Lowe C, Wood KM, Bacon CM. Am J Surg Pathol. 2011 May 5. PMID: 21552113