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hyalinizing spindle cell tumor with giant rosettes

Tuesday 10 May 2011


Definition: Hyalinising spindle cell tumour with giant rosettes (HSCTGR) is an uncommon, recently described low-grade sarcoma which shares many histological features with low-grade fibromyxoid sarcoma (LGFMS).


- Hyalinising spindle cell tumor with giant collagen rosettes HSCTGR

HSCTGR is composed of spindled stromal cells amongst which were scattered so-called collagen rosettes.

HSCTGR forms part of the spectrum of sarcomas showing fibroblastic differentiation.

Differential diagnosis

- low-grade fibromyxoid sarcoma

  • The low-grade fibromyxoid sarcomas are uncommon deep-seated soft tissue neoplasms that exhibit a deceptively benign appearance microscopically. The finding of a linear or whorled array of spindled cells with few or no mitoses in a characteristic myxoid stroma can pose diagnostic dilemmas. Recurrences are common, and late metastases have been recorded.
  • Both the neoplasms having a similar cytogenetic abnormality and clinical behavior.
  • Because of the similarities, both lesions are considered to be a single entity within the spectrum of low-grade sarcomas.

See also

- low-grade fibromyxoid sarcoma


- Hyalinizing spindle cell tumor with giant rosettes. Ramaswamy AS, Chatura KR. Ann Saudi Med. 2011 Jan-Feb;31(1):83-6. PMID: 20864787 [Free]

- Hyalinizing spindle cell tumor with giant rosettes arising in the lung: report of a case with FUS-CREB3L2 fusion transcripts. Kim L, Yoon YH, Choi SJ, Han JY, Park IS, Kim JM, Chu YC, Kim YJ. Pathol Int. 2007 Mar;57(3):153-7. PMID: 17295648