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t(12;15)(p13;q25)

Tuesday 3 May 2011

AGCOH Mitelman database (CGAP - NCBI) CancerChromosomes (NCBI)

The t(12;15)(p13;q25) forms the ETV6-NTRK3 fusion gene.

References

- A unique translocation of the TEL gene in a case of acute myelogenous leukemia with inv(12)(p13q15). Setoyama M, Tojo A, Nagamura F, Asano S, Ishimae M, Eguchi M, Kamada N. Blood. 1998 ; 92 (4) : 1454-1455. PMID 9694736

- Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Eguchi M, Eguchi-Ishimae M, Tojo A, Morishita K, Suzuki K, Sato Y, Kudoh S, Tanaka K, Setoyama M, Nagamura F, Asano S, Kamada N. Blood. 1999 ; 93 (4) : 1355-1363. PMID 9949179

- ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Lannon CL, Sorensen PH. Seminars in cancer biology. 2005 ; 15 (3) : 215-223. PMID 15826836