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PNET-testicular germ cell tumor association

Thursday 17 March 2011

Primitive neuroectodermal tumors (PNETs) are one of the most frequent types of ’non-germ cell’ tumor in patients with testicular germ cell tumors and have a guarded prognosis when present in metastatic sites after cisplatin-based chemotherapy.

PNETs derived from testicular germ cell tumors mostly resemble central nervous system PNETs and generally lack the chromosome 22 translocation of peripheral PNETs. Future treatment strategies should take these findings into account. (20348883)

See also

- primitive neuroectodermal tumor (PNET)
- testicular germ cell tumors

References

- Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. Ulbright TM, Hattab EM, Zhang S, Ehrlich Y, Foster RS, Einhorn LH, Cheng L. Mod Pathol. 2010 Jul;23(7):972-80. PMID: 20348883