Thursday 17 March 2011
A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. (#21113140#)
SMARCA5 could have a potential role in proliferation and malignancy in gastric carcinogenesis.
- Higher immunoreactivity of SMARCA5 has been observed in gastric cancer samples than in normal mucosa.
- SMARCA5 promoter methylation is associated with the absence of protein expression.
SMARCA5 methylation and expression in gastric cancer. Gigek CO, Lisboa LC, Leal MF, Silva PN, Lima EM, Khayat AS, Assumpção PP, Burbano RR, Smith Mde A. Cancer Invest. 2011 Feb;29(2):162-6. PMID: #21261476#
A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. Sumegi J, Nishio J, Nelson M, Frayer RW, Perry D, Bridge JA. Mod Pathol. 2011 Mar;24(3):333-42. PMID: #21113140# (Free)