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SMARCA5

Thursday 17 March 2011

Pathology

- A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. (21113140)

- SMARCA5 could have a potential role in proliferation and malignancy in gastric carcinogenesis.

  • Higher immunoreactivity of SMARCA5 has been observed in gastric cancer samples than in normal mucosa.
  • SMARCA5 promoter methylation is associated with the absence of protein expression.

References

- SMARCA5 methylation and expression in gastric cancer. Gigek CO, Lisboa LC, Leal MF, Silva PN, Lima EM, Khayat AS, Assumpção PP, Burbano RR, Smith Mde A. Cancer Invest. 2011 Feb;29(2):162-6. PMID: 21261476

- A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. Sumegi J, Nishio J, Nelson M, Frayer RW, Perry D, Bridge JA. Mod Pathol. 2011 Mar;24(3):333-42. PMID: 21113140 (Free)