- Human pathology

Home > E. Pathology by systems > Digestive system > Colon and rectum > tremelimumab-associated colitis

tremelimumab-associated colitis

Tuesday 1 March 2011


- Tremelimumab (anti-CTLA4) associated colitis. Intra-epithelial & lamina propria neutrophilia. Lymphoplasmacytosis of lamina propria


Tremelimumab is a fully human IgG2 monoclonal antibody produced by Pfizer. Tremelimumab binds to the protein CTLA-4 , which is expressed on the surface of activated T lymphocytes.

Tremelimumab blocks the binding of the antigen-presenting cell ligands B7.1 and B7.2 to CTLA-4, resulting in inhibition of B7-CTLA-4-mediated downregulation of T-cell activation.

See also

- anti-CTLA-4 / CTLA-4 blockade