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Mycobacterium lentiflavum infection

Tuesday 1 February 2011

Definition: Mycobacterium lentiflavum is a recently described nontuberculous mycobacterium (NTM) that has mainly clinical importance in young children with cervical lymphadenitis and in immunocompromised patients.

A case of chronic pulmonary infection has been described in an immunocompetent patient.

Mycobacterium lentiflavum was described as a nontuberculous mycobacterium in 1966.

Most of the isolates represented fortuitous isolations, although recently its identification has posed concerns about its possible clinical importance.

M. lentiflavum was mainly isolated from lymph nodes of young children, while isolations from other sites (lung specimens included) were described only in immunocompromised patients.

References

- Mycobacterium lentiflavum infection in immunocompetent patient. Molteni C, Gazzola L, Cesari M, Lombardi A, Salerno F, Tortoli E, Codecasa L, Penati V, Franzetti F, Gori A. Emerg Infect Dis. 2005 Jan;11(1):119-22. PMID: 15705334 [Free]

- Springer B, Wu WK, Bodmer T, Haase G, Pfyffer GE, Kroppenstedt RM, et al. Isolation and characterization of a unique group of slowly growing mycobacteria: description of Mycobacterium lentiflavum sp. nov. J Clin Microbiol. 1996;34:1100–7.

- Tortoli E, Piersimoni C, Kirschner P, Bartoloni A, Burrini C, Lacchini, et al. Characterization of mycobacteria isolates phylogenetically related to, but different from Mycobacterium simiae. J Clin Microbiol. 1997;35:697–702.

- Cabria F, Torres MV, Garcia-Cia JI, Dominguez-Garrido MN, Esteban J, Jimenez MS. Cervical lymphadenitis caused by Mycobacterium lentiflavum. Pediatr Infect Dis. 2002;21:574–5.

- Haase G, Kentrup H, Skopnik H, Springer B, Böttger C. Mycobacterium lentiflavum: an etiological agent of cervical lymphadenitis. Clin Infect Dis. 1997;25:1245–6.

- Tortoli E, Bartoloni A, Erba ML, Levre E, Lombardi N, Mantella A, et al. Human infections due to Mycobacterium lentiflavum. J Clin Microbiol. 2002;40:728–9.

- Uria MJ, Garcia J, Menendez JJ, Jimenez MS. Mycobacterium lentiflavum infection: case history and review of the medical literature. Enferm Infecc Microbiol Clin. 2003;21:274–5.

- Ibanez R, Serrano-Heranz R, Jimenez-Palop M, Roman C, Corteguera M, Jimenez S. Disseminated infection caused by slow-growing Mycobacterium lentiflavum. Eur J Clin Microbiol Infect Dis. 2002;21:691–2.

- Niobe SN, Bebear CM, Clerc M, Pellegrin JL, Bebear C, Maugein J. Disseminated Mycobacterium lentiflavum infection in a human immunodeficiency virus-infected patient. J Clin Microbiol. 2001;39:2030–2.

- Galarraga MC, Torreblanca A, Jimenez MS. Isolation of Mycobacterium lentiflavum in a case of suspected lung cancer. Enferm Infecc Microbiol Clin. 2002;20:93–4.