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idiopathic myelopathies with white matter vacuolation

Monday 24 January 2011

Although the etiology of these myelopathies is unknown, their association with immune suppression and coexistent viral infection of the central nervous system suggests that an opportunistic viral infection may be important.

See also

- vacuolar myelopathy
- acquired immunodeficiency syndrome

Associations

- leukemia
- lymphoma
- carcinoma
- systemic lupus erythematosus
- chronic lung disease
- transplantation
- cirrhosis
- diabetes
- hemophagocytic syndrome
- viral encephalitis
- long-term steroid therapy
- immunosuppressive chemotherapy

Signs and symptoms

- paraparesis
- ataxia
- bilateral extensor plantar reflexes

Microscopic examination

- vacuolation in spinal cord white matter primarily located in posterior and lateral columns.
- Lipid-laden macrophages and axonal changes were proportional to the severity of the vacuolation.

See also

- myelopathies

References

- Idiopathic myelopathies with white matter vacuolation in non-acquired immunodeficiency syndrome patients. Kamin SS, Petito CK. Hum Pathol. 1991 Aug;22(8):816-24. PMID: 1869265