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trisomy 9

Wednesday 19 January 2011

AGCOH

Trisomy 9 occurs in a large spectrum of myeloid and lymphatic malignancies:
- chronic myeloproliferative disorders (CMPD), especially to polycythemia vera (PV)
- acute myeloid leukemias (AML)
- myelodysplastic syndromes (MDS)
- acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage.

Strong association to the chronic myeloproliferative disorders (CMPD) and especially to polycythemia vera (PV).

References

- True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor. Suenaga M, Matsushita K, Kawamata N, Kukita T, Hamakawa Y, Gejima K, Onodera R, Sato T, Yamaguchi A, Inoue H, Arimura K, Arima N, Yoshida H, Tei C. Acta Haematol. 2006;116(1):62-6.PMID: 16809892