Home > A. Molecular pathology > Variants-Mutants > AKT1-pS473

AKT1-pS473

Friday 14 January 2011

IHCDB

Akt protein (AKT1) is phosphorylated at serine residue 473.

AKT1, also known as protein kinase B (PKB) or Rac-α, is a serine/threonine protein kinase that functions as an important regulator of various cell processes including apoptosis, proliferation, differentiation and metabolism.

AKT1 is a critical downstream effector of PI3-kinase (PI-3K), which mediates signal transduction initiated by a variety of stimuli including hormones, growth factors and cytokines.

PI-3K activates AKT1 through a second messenger, which results in phosphorylation of AKT1 at threonine 308 and at serine 473 by upstream protein kinases.

Activated AKT1 phosphorylates a number of protein substrates including BAD, caspase-9, forkhead transcription factors, GSK-3-α-β, CREB and mTOR/FRAP.

IHC antibodies

- Dako:14-5