Friday 14 January 2011
Akt protein (AKT1) is phosphorylated at serine residue 473.
AKT1, also known as protein kinase B (PKB) or Rac-α, is a serine/threonine protein kinase that functions as an important regulator of various cell processes including apoptosis, proliferation, differentiation and metabolism.
AKT1 is a critical downstream effector of PI3-kinase (PI-3K), which mediates signal transduction initiated by a variety of stimuli including hormones, growth factors and cytokines.
PI-3K activates AKT1 through a second messenger, which results in phosphorylation of AKT1 at threonine 308 and at serine 473 by upstream protein kinases.
Activated AKT1 phosphorylates a number of protein substrates including BAD, caspase-9, forkhead transcription factors, GSK-3-α-β, CREB and mTOR/FRAP.