Humpath.com - Human pathology

Home > D. General pathology > Infectious diseases > chronic active EBV-infection

chronic active EBV-infection

Friday 24 December 2010

After an acute EBV infection, patients can sometimes have persistent EBV infection without underlying immunodeficiency. Initially chronic active Epstein-Barr virus infection was thought to be an infection of B cells , but it is now recognized that they can infect T cells, NK cells and epithelial cells.

The disease is defined as a severe illness greater than 6 months duration that: 1) follows an acute EBV infection with chronic infection of B, T or NK cells, 2) evidence of major organ involvement including fever, lymphadenopathy, and hepatosplenomegaly, 3) increased levels of EBV DNA in peripheral blood and or EBV-EBER or protein positive cells in tissue.

Chronic EBV syndromes are recognized as B-cell and T/NK cell types.

The B cell type of CAEBV is much rarer than the T cell type. The B cell type occurs in Western countries in older individuals than the T cell type.

The T cell type has ethnic associations and occurs mainly in Asians and Native Americans in Mexico, Central and South America. Most EBV-associated T cell lymphomas arise after chronic active EBV infection.

References

- http://www.semdiagpath.com/article/S0740-2570(14)00108-7/fulltext

- Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection. Iwata S, Wada K, Tobita S, Gotoh K, Ito Y, Demachi-Okamura A, Shimizu N, Nishiyama Y, Kimura H. J Gen Virol. 2010 Jan;91(Pt 1):42-50. PMID: 19793909

- Blood stem-cell transplantation for chronic active Epstein-Barr virus with lymphoproliferation. Okamura T, Hatsukawa Y, Arai H, Inoue M, Kawa K. Lancet. 2000 Jul 15;356(9225):223-4. PMID: 10963205

- Ganciclovir for chronic active Epstein-Barr virus infection. Ishida Y, Yokota Y, Tauchi H, Fukuda M, Takaoka T, Hayashi M, Matsuda H. Lancet. 1993 Feb 27;341(8844):560-1. PMID: 8094799

- Malignant histiocytosis in a patient with chronic active Epstein-Barr virus infection. Fujisaki T, Nagafuchi S, Niho Y, Tsuneyoshi M, Oshima K, Kikuchi M. Lancet. 1992 Nov 7;340(8828):1168-9. PMID: 1359251