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IgA plasmacytoma

Tuesday 30 November 2010

Definition: plasmacytomas expressing immunoglobulin A.

Localization

- nodal IgA plasmacytoma
- extranodal IgA plasmacytoma

Types

- IgA plasmacytoma

Plasmacytomas expressing immunoglobulin A are rare and not well characterized. Nodal and extranodal plasmacytomas expressing immunoglobulin A are an indolent lymphoproliferative disorder with a low risk of clinical progression.

IgA plasmacytomas may represent a distinct form of extramedullary plasmacytoma characterized by younger age at presentation, frequent lymph node involvement, and low risk of progression to plasma cell myeloma. (20871216)

References

- Nodal and extranodal plasmacytomas expressing immunoglobulin A: an indolent lymphoproliferative disorder with a low risk of clinical progression. Shao H, Xi L, Raffeld M, Pittaluga S, Dunleavy K, Wilson WH, Spector N, Milito C, Morais JC, Jaffe ES. Am J Surg Pathol. 2010 Oct;34(10):1425-35.PMID: 20871216