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Home > E. Pathology by systems > Digestive system > Small intestine > Duodenum > Ampulla of Vater > intra-ampullary papillary-tubular tumor

intra-ampullary papillary-tubular tumor

Monday 22 November 2010

Tumoral intraepithelial neoplasia occurring within the ampulla are highly analogous to pancreatic or biliary intraductal papillary and tubular neoplasms as evidenced by their papillary and/or tubular growth, variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence).

IAPNs are biologically indolent; noninvasive examples show an excellent prognosis, whereas those with invasion exhibit a malignant but nevertheless significantly better prognosis than typical invasive ampullary carcinomas unaccompanied by IAPNs.

Twenty eight percent of invasive carcinomas within the ampulla arise in association with IAPNs. (21084962)


- Intra-ampullary Papillary-Tubular Neoplasm (IAPN): Characterization of Tumoral Intraepithelial Neoplasia Occurring Within the Ampulla: A Clinicopathologic Analysis of 82 Cases. Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV. Am J Surg Pathol. 2010 Nov 16. PMID: 21084962