idiopathic cervical fibrosis
Monday 15 November 2010
Definition: Idiopathic cervical fibrosis is a rare tumefactive inflammatory-sclerosing lesion involving the soft tissues of the head and neck.
A proportion of patients also have synchronous or metachronous inflammatory fibrosclerosing lesions in other anatomic sites. The latter finding suggests that this entity may represent a member of IgG4-related sclerosing diseases.
42 to 89 years
an infiltrative, firm cervical mass
IgG4-related chronic sclerosing sialadenitis of submandibular gland and lymphadenopathy
coalescent nodular lymphoid aggregates
skeletal muscle invasion
significant increase in IgG4 plasma cells (87 to 327 per high-power field, with IgG4/IgG ratio of 63% to 98%)
IgG4-related sclerosing diseases
Idiopathic cervical fibrosis—a new member of igg4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Cheuk W, Tam FK, Chan AN, Luk IS, Yuen AP, Chan WK, Hung TC, Chan JK. Am J Surg Pathol. 2010 Nov;34(11):1678-85. PMID: 20871392