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CDC25A

MIM.116947 HGNC:1725 3p21

Saturday 6 November 2010

Cell division cycle 25 phosphatases (CDC25s) regulate key transitions between cell cycle phases during normal cell division, and in the event of DNA damage they are key targets of the checkpoint machinery that ensures genetic stability.

Pathology

- CDC25s overexpression has been reported in a significant number of human cancers.

See also

- CDC25s: CDC25A, CDC25B, CDC25C

References

- Boutros R, Lobjois V, Ducommun B. CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer. 2007 Jul;7(7):495-507. PMID: 17568790

- Rudolph J. Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases. Nat Rev Cancer. 2007 Mar;7(3):202-11. PMID: 17287826

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