Sunday 31 October 2010
Craniofacial structures, including teeth are often affected by malformations.
Genetic variants that are sufficient for the formation of other organs may not be able to function properly during craniofacial development, with or without additional environmental cofactors such as physical constraint in utero, nutritional deficiencies, pharmacological agents, toxins, infections and radiation.
Alternatively, the same gene variant(s) may also cause disturbances elsewhere in the body plan. The craniofacial malformations, however, are usually perceived as the most unsettling ones.
Genetics and human malformations. Mues G, Kapadia H, Wang Y, D’Souza RN. J Craniofac Surg. 2009 Sep;20 Suppl 2:1652-4. PMID: #19816326# [Free]
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