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sarcomatoid acquired cystic disease-associated renal cell carcinoma

Thursday 28 October 2010

Synopsis

- acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) with sarcomatoid change
- oncocytic cuboidal cells
- tubular, cribriform or papillary growth patterns
- atypical columnar cells with abundant cytoplasm proliferated with papillary configuration
- oxalate crystal deposition stroma
- sarcomatous neoplastic cells

Immunochemistry

- The cytoplasm of oncocytic and sarcomatous neoplastic cells is diffusely positive for anti-mitochondrial antibody.

Ultrastructure

- many mitochondria in the cytoplasm of oncocytic carcinoma cells and sarcomatous neoplastic cells

Cytogenetics

The loss of chromosomes 1p, 2q11-22, 9 and 14 was observed using comparative genomic hybridization analysis.

Differential diagnosis

- TFE3-associated renal cell carcinoma (TFE3-RCC)

See also

- acquired cystic disease-associated renal cell carcinoma

References

- Sarcomatoid acquired cystic disease-associated renal cell carcinoma. Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH. Histol Histopathol. 2008 Nov;23(11):1327-31.PMID: 18785115

- Sarcomatoid renal cell carcinoma arising in hemodialysis-associated acquired cystic kidney disease presenting with disseminated bone marrow infiltration. Suvarna, S. K. , M. Ahuja , and C. B. Brown . Am J Kidney Dis 1994. 24:581–585.