Wednesday 6 October 2010
PRSS55 is a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
The human T-SP1 gene encompasses 28.7 kb on the short arm of chromosome 8 and consists of seven exons.
Expression of the T-SP1 protein was found in the Leydig and Sertoli cells of the testis and in the epithelial cells of the ductuli efferentes.
Notably, T-SP1 protein was also detectable in prostate cancer and in some ovarian cancer tissues, indicating tumor-related synthesis of T-SP1 beyond testis tissue.
T-SP1: a novel serine protease-like protein predominantly expressed in testis. Neth P, Profanter B, Geissler C, Nägler DK, Nerlich A, Sommerhoff CP, Jochum M. Biol Chem. 2008 Dec;389(12):1495-504. PMID: #18844450#