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HPV-associated squamous cell carcinoma of the upper aerodigestive tract

Tuesday 7 September 2010

The majority of HPV-associated SCCs are oropharyngeal (base of tongue and palatine tonsils), although both sinonasal and laryngeal tumors were also associated with infection (67% and 33% of cases, respectively).

Given the better prognosis of HPV-associated SCCs of the upper aerodigestive tract, it may be prudent to report the p16 and HPV status of these tumors when they are encountered.

See also

- squamous cell carcinoma of the upper aerodigestive tract

References

- Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract. Stelow EB, Jo VY, Stoler MH, Mills SE. Am J Surg Pathol. 2010 Jul;34(7):e15-24. PMID: #20534998# (Review)

- Papillary Squamous Cell Carcinoma of the Head and Neck: Frequent Association With Human Papillomavirus Infection and Invasive Carcinoma. Jo VY, Mills SE, Stoler MH, Stelow EB. Am J Surg Pathol. 2009 Sep 9. PMID: #19745700#