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oropharyngeal squamous cell carcinoma

Tuesday 7 September 2010

p16

Outcomes for p16 positive, HPV negative oropharyngeal SCC are not significantly different from p16 positive, HPV positive tumors and are significantly better than for p16 negative tumors. (#20588174#)

These results suggest that p16 immunohistochemistry alone is the best test to use for risk stratification in oropharyngeal SCC.

See also

- HPV-associated oropharyngeal squamous cell carcinoma
- p16+ oropharyngeal squamous cell carcinoma

References

- Tumor cell anaplasia and multinucleation are predictors of disease recurrence in oropharyngeal squamous cell carcinoma, including among just the human papillomavirus-related cancers. Lewis JS Jr, Scantlebury JB, Luo J, Thorstad WL. Am J Surg Pathol. 2012 Jul;36(7):1036-46. PMID: #22743286#

- p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status. Lewis JS Jr, Thorstad WL, Chernock RD, Haughey BH, Yip JH, Zhang Q, El-Mofty SK. Am J Surg Pathol. 2010 Aug;34(8):1088-96. PMID: #20588174#