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bile duct adenoma

Thursday 2 September 2010

The so-called bile duct adenoma and peribiliary glands are characterized by the expression of two foregut antigens (designated D10 and 1F6) and secretion of acid mucin.

On account of this similarity in phenotype and their frequent close association with a large caliber bile duct, it was earlier suggested that bile duct adenoma represent a peribiliary gland hamartoma.

The distinguishing feature of so-called bile duct adenoma is their display of the same phenotype as pyloric gland metaplasia. They develop as a localized biliary healing response equivalent to the function of a peribiliary gland or pyloric gland metaplasia in the foregut.

Differential diagnosis

Bile Duct Adenoma vs Metastatic PDAC

Histologic Features Bile duct adenoma Metastatic PDAC
Size Small Larger
Cellularity High High
Angulated glands Typically Absent Present
Desmoplastic stroma Absent Present
Nuclear pleomorphism Absent Present
Nuclear atypia Absent Present
Mitosis Absent Present


- An Immunohistochemical Profile of the So-called Bile Duct Adenoma: Clues to Pathogenesis. Hughes NR, Goodman ZD, Bhathal PS. Am J Surg Pathol. 2010 Sep;34(9):1312-8. PMID: 20679879