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lymphomas of the gall bladder and extrahepatic bile ducts

Thursday 2 September 2010

Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare.

The most common primary lymphoma types were:
- diffuse large B-cell lymphoma
- extranodal marginal zone lymphoma
- B-lymphoblastic lymphoma
- follicular lymphoma.

Some cases have features of lymphomatous polyposis with follicular lymphoma or mantle cell lymphoma, with disease limited to the mantle zones, so-called in situ mantle cell lymphoma.

Other rare lymphoma subtypes in this site can be the extracavitary variant of primary effusion lymphoma and plasmablastic lymphoma.

Patients with diffuse large B-cell lymphoma and extranodal marginal zone lymphoma are older (mean age 75.8 y) than those with other subtypes (mean age 47 y) and more likely to have gallstones (60% vs. 12.5%).

Primary lymphomas of the gall bladder and extrahepatic bile ducts show a broad spectrum of disease types, but in many respects mirror the spectrum of primary lymphomas of the gastrointestinal tract.

References

- Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications. Mani H, Climent F, Colomo L, Pittaluga S, Raffeld M, Jaffe ES. Am J Surg Pathol. 2010 Sep;34(9):1277-86. PMID: #20679881#